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ENTHEOGENIC TRYPTAMINE • "THE GOD MOLECULE"

5-MeO-DMT

5-methoxy-N,N-dimethyltryptamine

C₁₃H₁₈N₂O • 218.30 g/mol • CAS 1019-45-0 • CID 1832
Target: 5-HT₁ₐ • 5-HT₂ₐ agonist
Origin: Incilius alvarius
✦ Subjective Phenomenology
Onset: 15–30s • Duration: 15–45m

Instant and total dissolution of the ego structure into non-dual oceanic boundlessness, radiant void consciousness, and unitive mystical transcendence. Often described as the most potent entheogen known.

LORE Naturally secreted by the Sonoran Desert toad (Incilius alvarius). Modern harm reduction prioritizes synthetic 5-MeO-DMT to avoid cardiotoxic toad bufadienolides and protect wild amphibian populations.

“In the kingdom of the mind, 5-MeO-DMT is the absolute sovereign.”

— Alexander Shulgin, TiHKAL

5-MeO-DMT • Pharmacodynamic Profile

5-HT₁ₐ Receptor (Serotonin 1A) Ki = 0.5 nM (Extreme)
5-HT₂ₐ Receptor (Serotonin 2A) Ki = 32 nM (Moderate)
5-HT₂𝒸 Receptor Ki = 110 nM (Low)
Na⁺/K⁺-ATPase (Cardiotoxicity Target) Inactive (>10,000 nM)
5-MeO-DMT demonstrates overwhelming selectivity for the inhibitory 5-HT₁A receptor over 5-HT₂A, suppressing default mode network (DMN) hyperactivity and creating unitive non-dual ego dissolution rather than intricate geometric hallucinations.
5-MeO-DMT • Non-Dual Void Mode

“There is only the unitive light, devoid of observer or observed.”

— Pure Transcendence Consciousness
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